When I first heard about the talk I thought that it was a good idea. Now that I've actually seen the talk, I consider it even a better idea. The basic idea is to map all your mail in to actions.
Even though I've managed to dodge most of the caveats of e-mail management, I have a lot of work to do. The biggest problem for me is that I'm a packrat when it comes to my e-mail. I never discard my mail, I archive everything but spam. I have certain scheduled jobs that move the old mail out of my mailboxes in to archive so I'm not a lost cause when it comes to mailbox size.
Another thing that I need to start using more is a to do list. While watching that talk, I noticed that I tend to leave mails that need me to do something laying in my inbox. Usually those mails stay there until they rot.
All in all, even though the model doesn't fit all, it appears to fit me. I'll give it a shot and see if it really works.
You can find out more on the Inbox Zero website.